SELECTIVE INHIBITION OF THERMOGENESIS BY TRIBUTYL S,S,S,-PHOSPHOROTRITHIOATE (DEF)

Effects of the synergists piperonyl butoxide and S,S,S-tributyl phosphorotrithioate on propoxur pharmacokinetics in Blattella germanica (Blattodea: Blattellidae).

Effects of the synergists piperonyl butoxide (PBO) and S,S,S-tributyl phosphorotrithioate (DEF) on propoxur pharmacokinetics were examined in the German cockroach, Blattella germanica (L.). Treatment of adult male German cockroaches with the cytochrome P450 monooxygenase inhibitor, PBO, or the esterase inhibitor, DEF, increased propoxur toxicity by 2- and 6.8-fold, respectively, implicating hyd...

Adrenergic Receptor-Mediated Inhibition of Thermogenesis

2 adrenergic receptor ( 2-AR) agonists have been used as antihypertensive agents, in the management of drug withdrawal, and as sedative analgesics. Since 2-AR agonists also influence the regulation of body temperature, we explored their potential as antipyretic agents. This study delineates the central neural substrate for the inhibition of rat brown adipose tissue (BAT) and shivering thermogen...

Selective Inhibition by Clofibric Acid

shown to actively utilize branched chaini amino acids and to produce alanine. The coniversioni of [1-"C]leucine to 14CO2 or to the [1-14C]keto-acid of leucine (a-keto-isocaproate) was linear for at least 2 h of incubation; the production of "CO2 from [1-'4C]leucine was saturable with a Km = 6.3 mM and a maximiium oxidation rate (Vmax) = 31 nmiol/mg protein per 120 min. Clofibric acid selectivel...

Stream Processing with Bigdata by SSS-MapReduce

We propose a MapReduce based stream processing system, called SSS, which is capable of processing stream along with large scale static data. Unlike the existing stream processing systems that can work only on the relatively small on-memory data-set, SSS can process incoming streamed data consulting the stored data. SSS processes streamed data with continuous Mappers and Reducers, that are perio...

Selective inhibition of glycosidases by feedback prodrugs.